The Collaborative International Dictionary of English v.0.48:

Handcuff \Hand"cuff`\ (-k[u^]f`), n. [AS. handcops; hand hand +
   cosp, cops, fetter. The second part was confused with E.
   cuffs,]
   A fastening, consisting of an iron ring around the wrist,
   usually connected by a chain with one on the other wrist; a
   manacle; -- usually in the plural.
   [1913 Webster]

The Collaborative International Dictionary of English v.0.48:

Handcuff \Hand"cuff`\ (h[a^]nd"k[u^]f`), v. t. [imp. & p. p.
   Handcuffed (-k[u^]ft`); p. pr. & vb. n. Handcuffing.]
   To apply handcuffs to; to manacle. --Hay (1754).
   [1913 Webster]

WordNet (r) 3.0 (2006):

handcuff
    n 1: shackle that consists of a metal loop that can be locked
         around the wrist; usually used in pairs [syn: handcuff,
         cuff, handlock, manacle]
    v 1: confine or restrain with or as if with manacles or
         handcuffs; "The police handcuffed the suspect at the scene
         of the crime" [syn: manacle, cuff, handcuff]

Moby Thesaurus II by Grady Ward, 1.0:

71 Moby Thesaurus words for "handcuff":
   Oregon boat, anchor, bilbo, bind, bond, bonds, bridle, camisole,
   chain, chains, collar, cuffs, deflate, disarm, enchain, entrammel,
   fasten, fetter, gag, gyve, gyves, halter, hamper, hamstring,
   handcuffs, hobble, hobbles, hog-tie, hopple, hopples, irons,
   knock out, lash, leading strings, leash, make fast, manacle, moor,
   muzzle, paralyze, peg down, picket, pillory, pin down, pinion,
   prostrate, put in irons, reins, restrain, restraint, restraints,
   rope, secure, shackle, silence, stocks, straightjacket,
   strait-waistcoat, straitjacket, strangle, stranglehold, strap,
   tether, throttle, tie, tie down, tie up, trammel, trammels,
   truss up, yoke