The Collaborative International Dictionary of English v.0.48:

Handcuff \Hand"cuff`\ (h[a^]nd"k[u^]f`), v. t. [imp. & p. p.
   Handcuffed (-k[u^]ft`); p. pr. & vb. n. Handcuffing.]
   To apply handcuffs to; to manacle. --Hay (1754).
   [1913 Webster]