The Collaborative International Dictionary of English v.0.48:

Seedy \Seed"y\, a. [Compar. Seedier; superl. Seediest.]
   1. Abounding with seeds; bearing seeds; having run to seeds.
      [1913 Webster]

   2. Having a peculiar flavor supposed to be derived from the
      weeds growing among the vines; -- said of certain kinds of
      French brandy.
      [1913 Webster]

   3. Old and worn out; exhausted; spiritless; also, poor and
      miserable looking; shabbily clothed; shabby looking; as,
      he looked seedy; a seedy coat. [Colloq.]
      [1913 Webster]

            Little Flanigan here . . . is a little seedy, as we
            say among us that practice the law. --Goldsmith.
      [1913 Webster]

   Seedy toe, an affection of a horse's foot, in which a
      cavity filled with horn powder is formed between the
      laminae and the wall of the hoof.
      [1913 Webster]

WordNet (r) 3.0 (2006):

seedy
    adj 1: full of seeds; "as seedy as a fig" [ant: seedless]
    2: shabby and untidy; "a surge of ragged scruffy children"; "he
       was soiled and seedy and fragrant with gin"- Mark Twain [syn:
       scruffy, seedy]
    3: somewhat ill or prone to illness; "my poor ailing
       grandmother"; "feeling a bit indisposed today"; "you look a
       little peaked"; "feeling poorly"; "a sickly child"; "is
       unwell and can't come to work" [syn: ailing, indisposed,
       peaked(p), poorly(p), sickly, unwell, under the
       weather, seedy]
    4: morally degraded; "a seedy district"; "the seamy side of
       life"; "sleazy characters hanging around casinos"; "sleazy
       storefronts with...dirt on the walls"- Seattle Weekly; "the
       sordid details of his orgies stank under his very nostrils"-
       James Joyce; "the squalid atmosphere of intrigue and
       betrayal" [syn: seamy, seedy, sleazy, sordid,
       squalid]

Moby Thesaurus II by Grady Ward, 1.0:

154 Moby Thesaurus words for "seedy":
   Mickey Mouse, ailing, bad, base, beat-up, bedraggled, below par,
   blowzy, broken-down, careless, cheap, cheesy, chintzy, coarse,
   common, critically ill, debilitated, decayed, decaying, decrepit,
   deteriorated, dilapidated, dingy, dowdy, down, down-at-heel,
   down-at-the-heels, drabbletailed, draggled, draggletailed,
   drooping, droopy, enervated, enfeebled, faded, fagged, faint,
   fainting, faintish, fatigued, feeling awful, feeling faint,
   feeling something terrible, flagging, footsore, fourth-class,
   frayed, frazzled, frowzy, frumpish, frumpy, full of holes,
   good and tired, grubby, holey, ill, in danger, in rags, in shreds,
   in tatters, indisposed, inferior, informal, irregular, jaded,
   laid low, languid, loose, low-class, low-grade, low-quality,
   low-test, lumpen, mangy, mean, messy, mortally ill, mussy,
   neglected, negligent, not quite right, off-color, out of sorts,
   overgrown, paltry, patchy, poky, poor, poorly, punk, ragged,
   raggedy, ratty, ready to drop, rocky, ruinous, run ragged,
   run-down, sagging, scraggly, scruffy, second-best, second-class,
   shabby, shoddy, sick, sick unto death, sickish, sickly, slack,
   slatternly, sleazy, slipshod, sloppy, slovenly, sluttish, sordid,
   squalid, tacky, taken ill, tattered, tatty, third-class,
   third-rate, threadbare, tinny, tired, tired-winged, toilworn, torn,
   under the weather, unkempt, unneat, unrefreshed, unrestored,
   unsightly, untidy, unwell, way-weary, wayworn, weak, weakened,
   wearied, weariful, weary, weary-footed, weary-laden, weary-winged,
   weary-worn, wilted, wilting, worn, worn out, worn-down