The Collaborative International Dictionary of English v.0.48:

Careworn \Care"worn`\, a.
   Worn or burdened with care; as, careworn look or face.
   [1913 Webster]

WordNet (r) 3.0 (2006):

careworn
    adj 1: showing the wearing effects of overwork or care or
           suffering; "looking careworn as she bent over her
           mending"; "her face was drawn and haggard from
           sleeplessness"; "that raddled but still noble face";
           "shocked to see the worn look of his handsome young
           face"- Charles Dickens [syn: careworn, drawn,
           haggard, raddled, worn]

Moby Thesaurus II by Grady Ward, 1.0:

32 Moby Thesaurus words for "careworn":
   aggrieved, anguished, distressed, doleful, dolorous, drawn,
   dumb with grief, exhausted, fagged, grief-stricken, griefful,
   grieved, grievous, heavy-laden, in grief, jaded, lamentable,
   lugubrious, mournful, pinched, plaintive, plangent,
   plunged in grief, rueful, sorrowed, sorrowful, sorrowing, tearful,
   troubled, tuckered, woeful, worn