The Collaborative International Dictionary of English v.0.48:

Predisposition \Pre*dis`po*si"tion\, n. [Pref. pre- +
   disposition: cf. F. pr['e]disposition.]
   1. The act of predisposing, or the state of being
      predisposed; previous inclination, tendency, or
      propensity; predilection; -- applied to the mind; as, a
      predisposition to anger.

   Syn: inclination; tendency; predilection; propensity.
        [1913 Webster]

   2. Previous fitness or adaptation to any change, impression,
      or purpose; susceptibility; -- applied to material things;
      as, the predisposition of the body to disease.
      [1913 Webster]

WordNet (r) 3.0 (2006):

predisposition
    n 1: susceptibility to a pathogen [syn: sensitivity,
         predisposition]
    2: an inclination beforehand to interpret statements in a
       particular way
    3: a disposition in advance to react in a particular way