The Collaborative International Dictionary of English v.0.48:

Misery \Mi"ser*y\, n.; pl. Miseries. [OE. miserie, L. miseria,
   fr. miser wretched: cf. F. mis[`e]re, OF. also, miserie.]
   [1913 Webster]
   1. Great unhappiness; extreme pain of body or mind;
      wretchedness; distress; woe. --Chaucer.
      [1913 Webster]

            Destruction and misery are in their ways. --Rom.
                                                  iii. 16.
      [1913 Webster]

   2. Cause of misery; calamity; misfortune.
      [1913 Webster]

            When we our betters see bearing our woes,
            We scarcely think our miseries our foes. --Shak.
      [1913 Webster]

   3. Covetousness; niggardliness; avarice. [Obs.]
      [1913 Webster]

   Syn: Wretchedness; torture; agony; torment; anguish;
        distress; calamity; misfortune.
        [1913 Webster]

WordNet (r) 3.0 (2006):

misery
    n 1: a state of ill-being due to affliction or misfortune; "the
         misery and wretchedness of those slums is intolerable"
         [syn: misery, wretchedness, miserableness]
    2: a feeling of intense unhappiness; "she was exhausted by her
       misery and grief"

Moby Thesaurus II by Grady Ward, 1.0:

102 Moby Thesaurus words for "misery":
   Cassandra, Schmerz, ache, aches and pains, aching heart, adversity,
   affliction, agony, agony of mind, angst, anguish, anxiety, bale,
   bitterness, bleeding heart, broken heart, burden, calamity, care,
   carking care, catastrophe, cheerlessness, crushing, curse, cynic,
   dampener, damper, dejection, depression, depth of misery,
   desolation, despair, desperation, despondency, destitution,
   disaster, discomfort, discontent, displeasure, distress, dolor,
   extremity, gloom, gloomy Gus, grief, grimness, grouch, grump,
   hardship, heartache, heartfelt grief, heartgrief, heavy heart,
   humorlessness, hurt, hurting, indigence, infelicity, infestivity,
   joylessness, killjoy, lamentation, languishment, malaise,
   malcontent, melancholia, melancholy, mirthlessness, misfortune,
   ordeal, pain, pang, passion, penury, pessimist, pining, poverty,
   privation, prophet of doom, prostration, sadness, sordidness,
   sorrow, sorrowing, sourpuss, spoilsport, squalor, stitch,
   suffering, suicidal despair, throe, trial, tribulation, trouble,
   twinge, uncheerfulness, unhappiness, unjoyfulness, unmirthfulness,
   wet blanket, woe, wretchedness