The Collaborative International Dictionary of English v.0.48:

Despondent \De*spond"ent\, a. [L. despondens, -entis, p. pr. of
   despond[=e]re.]
   Marked by despondence; given to despondence; low-spirited;
   as, a despondent manner; a despondent prisoner. --
   De*spond"ent*ly, adv.
   [1913 Webster]

WordNet (r) 3.0 (2006):

despondent
    adj 1: without or almost without hope; "despondent about his
           failure"; "too heartsick to fight back" [syn:
           despondent, heartsick]

Moby Thesaurus II by Grady Ward, 1.0:

57 Moby Thesaurus words for "despondent":
   affording no hope, apathetic, bleak, blue, bowed-down, cast down,
   cheerless, comfortless, dashed, dejected, depressed, despairing,
   desperate, desponding, disconsolate, discouraged, disheartened,
   dismal, dispirited, down, downcast, downhearted, drooping, droopy,
   feeling low, forlorn, grieving, grim, heartless, hopeless,
   hypochondriac, hypochondriacal, in despair, in low spirits,
   in the depths, in the doldrums, in the dumps, languishing, low,
   low-spirited, melancholy, miserable, morose, mourning, pessimistic,
   pining, sad, sorrowful, spiritless, subdued, suicidal, unhappy,
   unhopeful, weary of life, without hope, woebegone, world-weary