The Collaborative International Dictionary of English v.0.48:

Estrange \Es*trange"\, v. t. [imp. & p. p. Estranged; p. pr. &
   vb. n. Estranging.] [OF. estrangier to remove, F.
   ['e]tranger, L. extraneare to treat as a stranger, from
   extraneus strange. See Strange.]
   1. To withdraw; to withhold; hence, reflexively, to keep at a
      distance; to cease to be familiar and friendly with.
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            We must estrange our belief from everything which is
            not clearly and distinctly evidenced. --Glanvill.
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            Had we . . . estranged ourselves from them in things
            indifferent.                          --Hooker.
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   2. To divert from its original use or purpose, or from its
      former possessor; to alienate.
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            They . . . have estranged this place, and have
            burned incense in it unto other gods. --Jer. xix. 4.
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   3. To alienate the affections or confidence of; to turn from
      attachment to enmity or indifference.
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            I do not know, to this hour, what it is that has
            estranged him from me.                --Pope.
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            He . . . had pretended to be estranged from the
            Whigs, and had promised to act as a spy upon them.
                                                  --Macaulay.
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WordNet (r) 3.0 (2006):

estranging
    adj 1: making one feel out of place or alienated; "the landscape
           was estranging"