The Collaborative International Dictionary of English v.0.48:

Effeminate \Ef*fem"i*nate\, v. t. [imp. & p. p. Effeminated;
   p. pr. & vb. n. Effeminating.]
   To make womanish; to make soft and delicate; to weaken.
   [1913 Webster]

         It will not corrupt or effeminate children's minds.
                                                  --Locke.
   [1913 Webster]