The Collaborative International Dictionary of English v.0.48:

get-up-and-go \get-up-and-go\ n.
   a character trait manifested in a readiness and ability to
   initiate action; an enterprising and energetic spirit; a
   go-getting attitude.

   Syn: energy; drive; enterprise; initiative. [PJC]

WordNet (r) 3.0 (2006):

get-up-and-go
    n 1: enterprising or ambitious drive; "Europeans often laugh at
         American energy" [syn: energy, push, get-up-and-go]

Moby Thesaurus II by Grady Ward, 1.0:

47 Moby Thesaurus words for "get-up-and-go":
   adventuresomeness, adventurousness, aggression, aggressiveness,
   ambitiousness, bang, dash, drive, dynamism, enterprise,
   enterprisingness, fire, force, forcefulness, get-up-and-get, getup,
   ginger, go, go-ahead, go-getting, go-to-itiveness, gumption,
   hustle, initiative, kick, pep, pepper, piss and vinegar, pizzazz,
   poop, punch, push, pushfulness, pushiness, pushingness, snap,
   spirit, spunk, starch, thrust, up-and-comingness, venturesomeness,
   venturousness, verve, vim, zing, zip