The Collaborative International Dictionary of English v.0.48:

Fatigue \Fa*tigue"\, v. t. [imp. & p. p. Fatigued; p. pr. &
   vb. n. Fatiguing, n.] [Cf. F. fatiguer. See Fatigue, n.]
   To weary with labor or any bodily or mental exertion; to
   harass with toil; to exhaust the strength or endurance of; to
   tire.

   Syn: To jade; tire; weary; bore. See Jade.
        [1913 Webster]

WordNet (r) 3.0 (2006):

fatigued
    adj 1: drained of energy or effectiveness; extremely tired;
           completely exhausted; "the day's shopping left her
           exhausted"; "he went to bed dog-tired"; "was fagged and
           sweaty"; "the trembling of his played out limbs"; "felt
           completely washed-out"; "only worn-out horses and
           cattle"; "you look worn out" [syn: exhausted, dog-
           tired, fagged, fatigued, played out, spent,
           washed-out, worn-out(a), worn out(p)]

Moby Thesaurus II by Grady Ward, 1.0:

73 Moby Thesaurus words for "fatigued":
   all in, ausgespielt, beat, buggered, burned-out, bushed, dead,
   debilitated, devitalized, disabled, done, done up, drained,
   drooping, droopy, effete, emptied, enervated, enfeebled,
   eviscerated, exhausted, fagged, faint, fainting, far-gone,
   feeling faint, flagging, footsore, frazzled, good and tired,
   incapacitated, jaded, knocked out, laid low, languid, languorous,
   lethargic, listless, played out, pooped, ready to drop, run ragged,
   run-down, sagging, sapped, seedy, shotten, sluggish, spent,
   strained, tired, tired-winged, toilworn, unrefreshed, unrestored,
   used up, wasted, way-weary, wayworn, weak, weakened, wearied,
   weariful, weary, weary-footed, weary-laden, weary-winged,
   weary-worn, wilting, worn, worn down, worn-down, worn-out