The Collaborative International Dictionary of English v.0.48:

Manacle \Man"a*cle\ (m[a^]n"[.a]*k'l), n. [OE. manicle, OF.
   manicle, F. manicle sort glove, manacle, L. manicula a little
   hand, dim. of manus hand; cf. L. manica sleeve, manacle, fr.
   manus. See Manual.]
   A handcuff; a shackle for the hand or wrist; -- usually in
   the plural.
   [1913 Webster]

         Doctrine unto fools is as fetters on the feet, and like
         manacles on the right hand.              --Ecclus. xxi.
                                                  19.
   [1913 Webster]

The Collaborative International Dictionary of English v.0.48:

Manacle \Man"a*cle\, v. t. [imp. & p. p. Manacled
   (m[a^]n"[.a]*k'ld); p. pr. & vb. n. Manacling.]
   To put handcuffs or other fastening upon, for confining the
   hands; to shackle; to confine; to restrain from the use of
   the limbs or natural powers.
   [1913 Webster]

         Is it thus you use this monarch, to manacle and shackle
         him hand and foot ?                      --Arbuthnot.
   [1913 Webster]

WordNet (r) 3.0 (2006):

manacle
    n 1: shackle that consists of a metal loop that can be locked
         around the wrist; usually used in pairs [syn: handcuff,
         cuff, handlock, manacle]
    v 1: confine or restrain with or as if with manacles or
         handcuffs; "The police handcuffed the suspect at the scene
         of the crime" [syn: manacle, cuff, handcuff]

Moby Thesaurus II by Grady Ward, 1.0:

80 Moby Thesaurus words for "manacle":
   Oregon boat, anchor, bilbo, bind, bond, bonds, bracelets, bridle,
   camisole, chain, chains, check, collar, confine, control, cuff,
   cuffs, curb, deflate, disarm, enchain, entrammel, fasten, fetter,
   fetters, gag, gyve, gyves, halter, hamper, hamstring, handcuff,
   handcuffs, hobble, hobbles, hog-tie, hopple, hopples, inhibit,
   irons, knock out, lash, leading strings, leash, make fast, moor,
   muzzle, paralyze, peg down, picket, pillory, pin down, pinion,
   prostrate, put in irons, reins, restrain, restraint, restraints,
   rope, secure, shackle, shackles, silence, stocks, straightjacket,
   strait-waistcoat, straitjacket, strangle, stranglehold, strap,
   tether, throttle, tie, tie down, tie up, trammel, trammels,
   truss up, yoke