The Collaborative International Dictionary of English v.0.48:

Manacle \Man"a*cle\ (m[a^]n"[.a]*k'l), n. [OE. manicle, OF.
   manicle, F. manicle sort glove, manacle, L. manicula a little
   hand, dim. of manus hand; cf. L. manica sleeve, manacle, fr.
   manus. See Manual.]
   A handcuff; a shackle for the hand or wrist; -- usually in
   the plural.
   [1913 Webster]

         Doctrine unto fools is as fetters on the feet, and like
         manacles on the right hand.              --Ecclus. xxi.
                                                  19.
   [1913 Webster]

The Collaborative International Dictionary of English v.0.48:

Manacle \Man"a*cle\, v. t. [imp. & p. p. Manacled
   (m[a^]n"[.a]*k'ld); p. pr. & vb. n. Manacling.]
   To put handcuffs or other fastening upon, for confining the
   hands; to shackle; to confine; to restrain from the use of
   the limbs or natural powers.
   [1913 Webster]

         Is it thus you use this monarch, to manacle and shackle
         him hand and foot ?                      --Arbuthnot.
   [1913 Webster]

WordNet (r) 3.0 (2006):

manacle
    n 1: shackle that consists of a metal loop that can be locked
         around the wrist; usually used in pairs [syn: handcuff,
         cuff, handlock, manacle]
    v 1: confine or restrain with or as if with manacles or
         handcuffs; "The police handcuffed the suspect at the scene
         of the crime" [syn: manacle, cuff, handcuff]