The Collaborative International Dictionary of English v.0.48:

Profanation \Prof`a*na"tion\, n. [L. profanatio: cf. F.
   profanation. See Profane, v. t.]
   1. The act of violating sacred things, or of treating them
      with contempt or irreverence; irreverent or too familiar
      treatment or use of what is sacred; desecration; as, the
      profanation of the Sabbath; the profanation of a
      sanctuary; the profanation of the name of God.
      [1913 Webster]

   2. The act of treating with abuse or disrespect, or with
      undue publicity, or lack of delicacy.
      [1913 Webster]

            'T were profanation of our joys
            To tell the laity our love.           --Donne.
      [1913 Webster]

WordNet (r) 3.0 (2006):

profanation
    n 1: blasphemous behavior; the act of depriving something of its
         sacred character; "desecration of the Holy Sabbath" [syn:
         profanation, desecration, blasphemy, sacrilege]
    2: degradation of something worthy of respect; cheapening