The Collaborative International Dictionary of English v.0.48:

Incapacitate \In`ca*pac"i*tate\, v. t. [imp. & p. p.
   Incapacitated; p. pr. & vb. n. Incapacitating.] [Pref.
   in- not + capacitate.]
   [1913 Webster]
   1. To deprive of capacity or natural power; to disable; to
      render incapable or unfit; to disqualify; as, his age
      incapacitated him for war.
      [1913 Webster]

   2. (Law) To deprive of legal or constitutional requisites, or
      of ability or competency for the performance of certain
      civil acts; to disqualify.
      [1913 Webster]

            It absolutely incapacitated them from holding rank,
            office, function, or property.        --Milman.
      [1913 Webster]

WordNet (r) 3.0 (2006):

incapacitate
    v 1: make unable to perform a certain action; "disable this
         command on your computer" [syn: disable, disenable,
         incapacitate] [ant: enable]
    2: injure permanently; "He was disabled in a car accident" [syn:
       disable, invalid, incapacitate, handicap]

Moby Thesaurus II by Grady Ward, 1.0:

44 Moby Thesaurus words for "incapacitate":
   afflict, bugger, castrate, cripple, de-energize, deactivate,
   debilitate, derange, devitalize, disable, disarm, disenable,
   disorder, drain, emasculate, enervate, enfeeble, exhaust,
   hamstring, hobble, hors de combat, hospitalize, immobilize, impair,
   inactivate, indispose, invalid, kibosh, lame, lay up, maim,
   prostrate, put, queer, queer the works, reduce, sabotage, sicken,
   spike, unfit, weaken, wing, wound, wreck