The Collaborative International Dictionary of English v.0.48:

Sophisticate \So*phis"ti*cate\, v. t. [imp. & p. p.
   Sophisticated; p. pr. & vb. n. Sophisticating.] [LL.
   sophisticatus, p. p. of sophisticare to sophisticate.]
   To render worthless by admixture; to adulterate; to damage;
   to pervert; as, to sophisticate wine. --Howell.
   [1913 Webster]

         To sophisticate the understanding.       --Southey.
   [1913 Webster]

         Yet Butler professes to stick to plain facts, not to
         sophisticate, not to refine.             --M. Arnold.
   [1913 Webster]

         They purchase but sophisticated ware.    --Dryden.
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   Syn: To adulterate; debase; corrupt; vitiate.
        [1913 Webster] Sophisticate

The Collaborative International Dictionary of English v.0.48:

Sophisticate \So*phis"ti*cate\, Sophisticated
\So*phis"ti*ca`ted\, a.
   Adulterated; not pure; not genuine.
   [1913 Webster]

         So truth, while only one supplied the state,
         Grew scare and dear, and yet sophisticate. --Dryden.
   [1913 Webster]

WordNet (r) 3.0 (2006):

sophisticated
    adj 1: having or appealing to those having worldly knowledge and
           refinement and savoir-faire; "sophisticated young
           socialites"; "a sophisticated audience"; "a sophisticated
           lifestyle"; "a sophisticated book" [ant: naif, naive]
    2: ahead in development; complex or intricate; "advanced
       technology"; "a sophisticated electronic control system"
       [syn: advanced, sophisticated]
    3: intellectually appealing; "a sophisticated drama"

Moby Thesaurus II by Grady Ward, 1.0:

133 Moby Thesaurus words for "sophisticated":
   adult, advanced, blase, bored, braw, brittle, byzantine, chic,
   chichi, civilized, classy, clothes-conscious, complex, complicated,
   cool, cosmopolitan, cosmopolite, cultivated, cultured, cynical,
   daedal, dainty, dapper, dashing, delicate, disabused, disappointed,
   discriminating, disenchanted, disillusioned, dressed to advantage,
   dressed to kill, elaborate, elegant, enlightened, experienced,
   exquisite, fastidious, fine, genteel, gordian, graceful, gracile,
   gracious, hardheaded, hep, hip, hoaxproof, intricate, involved,
   jaded, jaunty, knotty, knowing, knowledgeable, labyrinthine,
   mature, matured, mondaine, multifaceted, natty, neat, nice, nifty,
   nobby, not born yesterday, old, polished, posh, practical,
   practiced, put straight, realistic, recherche, refined, ripe,
   ripened, ritzy, robbed of illusion, sagacious, salty, schooled,
   seasoned, set right, sharp, skeptical, sleek, slick, smart, smooth,
   smug, snazzy, soigne, soignee, sophisticate, spiffy, spruce,
   style-conscious, suave, subtle, svelte, swank, swanky, swell,
   tough-minded, tricksy, tried, tried and true, trig, trim,
   uncharmed, uncullible, undeceivable, undeceived, undeludable,
   undupable, unfoolable, ungullible, unhoaxable, unseduceable,
   unsophisticated, unspelled, urbane, veteran, well-bred,
   well-dressed, well-groomed, wise, with it, world-weary, world-wise,
   worldly, worldly-wise