The Collaborative International Dictionary of English v.0.48:

Disruption \Dis*rup"tion\, n. [L. disruptio, diruptio.]
   The act or rending asunder, or the state of being rent
   asunder or broken in pieces; breach; rent; dilaceration;
   rupture; as, the disruption of rocks in an earthquake;
   disruption of a state.
   [1913 Webster]

WordNet (r) 3.0 (2006):

disruption
    n 1: an act of delaying or interrupting the continuity; "it was
         presented without commercial breaks"; "there was a gap in
         his account" [syn: break, interruption, disruption,
         gap]
    2: a disorderly outburst or tumult; "they were amazed by the
       furious disturbance they had caused" [syn: disturbance,
       disruption, commotion, flutter, hurly burly, to-do,
       hoo-ha, hoo-hah, kerfuffle]
    3: an event that results in a displacement or discontinuity
       [syn: dislocation, disruption]
    4: the act of causing disorder [syn: disruption,
       perturbation]

Moby Thesaurus II by Grady Ward, 1.0:

135 Moby Thesaurus words for "disruption":
   alienation, anarchism, anarcho-syndicalism, anarchy, antinomianism,
   badness, bloodbath, blue ruin, breach, breach of friendship, break,
   breakup, carnage, chaos, cleavage, cleft, confusion, consumption,
   crack-up, criminal syndicalism, damnation, decimation, depredation,
   derangement, desolation, despoilment, despoliation, destruction,
   devastation, diffusion, disaffection, disarrangement, disarray,
   disarticulation, discomfiture, discomposure, disconcertedness,
   discourtesy, disfavor, disharmony, dishevelment, disintegration,
   disjunction, disorder, disorderliness, disorderly conduct,
   disorganization, dispersal, disproportion, disruptiveness,
   dissolution, disturbance, disunion, disunity, divergence,
   dividedness, division, entropy, estrangement, exfoliation,
   falling-out, fragmentation, frowned-upon behavior, haphazardness,
   havoc, hecatomb, holocaust, hooliganism, horseplay, impropriety,
   incoherence, indiscriminateness, inharmonious harmony,
   irregularity, lynch law, misbehavior, misconduct, misdemeanor,
   misdoing, misrule, mob law, mob rule, mobocracy,
   most admired disorder, naughtiness, nihilism,
   nonsanctioned behavior, nonsymmetry, nonuniformity, ochlocracy,
   open rupture, perdition, perturbation, primal chaos, promiscuity,
   promiscuousness, randomness, ravage, rebellion,
   recall of ambassadors, revolution, rift, roughhouse, rowdiness,
   rowdyism, ruffianism, ruin, ruination, rupture, scaling,
   scattering, schism, separation, shambles, shattering, slaughter,
   split, spoliation, syndicalism, tohubohu, turbulence, turmoil,
   undoing, unruliness, unsymmetry, ununiformity, upset, vandalism,
   venial sin, vice, waste, wrack, wrack and ruin, wreck,
   wrongdoing