The Collaborative International Dictionary of English v.0.48:

Despite \De*spite"\, v. t. [imp. & p. p. Despited; p. pr. &
   vb. n. Despiting.] [OF. despitier, fr. L. despectare,
   intens. of despicere. See Despite, n.]
   To vex; to annoy; to offend contemptuously. [Obs.] --Sir W.
   Raleigh.
   [1913 Webster]

The Collaborative International Dictionary of English v.0.48:

Despite \De*spite"\, prep.
   In spite of; against, or in defiance of; notwithstanding; as,
   despite his prejudices.

   Syn: See Notwithstanding.
        [1913 Webster]

The Collaborative International Dictionary of English v.0.48:

Despite \De*spite"\, n. [OF. despit, F. d['e]pit, fr. L.
   despectus contempt, fr. despicere. See Despise, and cf.
   Spite, Despect.]
   1. Malice; malignity; spite; malicious anger; contemptuous
      hate.
      [1913 Webster]

            With all thy despite against the land of Israel.
                                                  --Ezek. xxv.
                                                  6.
      [1913 Webster]

   2. An act of malice, hatred, or defiance; contemptuous
      defiance; a deed of contempt.
      [1913 Webster]

            A despite done against the Most High. --Milton.
      [1913 Webster]

   In despite, in defiance of another's power or inclination.


   In despite of, in defiance of; in spite of. See under
      Spite. "Seized my hand in despite of my efforts to the
      contrary." --W. Irving.

   In your despite, in defiance or contempt of you; in spite
      of you. [Obs.]
      [1913 Webster]

WordNet (r) 3.0 (2006):

despite
    n 1: lack of respect accompanied by a feeling of intense
         dislike; "he was held in contempt"; "the despite in which
         outsiders were held is legendary" [syn: contempt,
         disdain, scorn, despite]
    2: contemptuous disregard; "she wanted neither favor nor
       despite"

Moby Thesaurus II by Grady Ward, 1.0:

123 Moby Thesaurus words for "despite":
   Schadenfreude, abhorrence, abomination, affront, airs, arrogance,
   aspersion, at all costs, at any cost, atrocity, audacity, aversion,
   bold front, boldness, brash bearing, brashness, brassiness,
   bravado, brazenness, brickbat, bumptiousness, cattiness,
   cheekiness, clannishness, cliquishness, cockiness, cold shoulder,
   contempt, contemptuousness, contumacy, contumely, cut, daring,
   daringness, defial, defiance, defying, derision, despisal,
   detestation, discourtesy, disdain, disdainfulness, disfavor,
   disgust, dislike, disparagement, disregard, distaste, dump,
   enormity, even with, flouting, gibe, gloating pleasure, grudge,
   harm, hate, hatred, hauteur, humiliation, hurt, ignoring, ill will,
   impertinence, impudence, in defiance of, in despite of,
   in spite of, incivility, indignity, injury, insolence, insult,
   irregardless, irrespective of, jeer, jeering, loathing,
   malevolence, maliciousness, malignancy, malignity, mock, mockery,
   notwithstanding, offense, outrage, pertness, put-down, rebuff,
   recalcitrance, regardless, regardless of, regardless of cost,
   rejection, repudiation, ridicule, sauciness, scoff, scorn,
   scornfulness, scurrility, slap, slight, sniffiness, snobbishness,
   snootiness, snottiness, snub, sovereign contempt, spite, spite of,
   spitefulness, spleen, spurning, stubbornness, superciliousness,
   taunt, toploftiness, uncomplimentary remark, unholy joy, with