The Collaborative International Dictionary of English v.0.48:

Depart \De*part"\, v. i. [imp. & p. p. Departed; p. pr. & vb.
   n. Departing.] [OE. departen to divide, part, depart, F.
   d['e]partir to divide, distribute, se d['e]partir to separate
   one's self, depart; pref. d['e]- (L. de) + partir to part,
   depart, fr. L. partire, partiri, to divide, fr. pars part.
   See Part.]
   1. To part; to divide; to separate. [Obs.] --Shak.
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   2. To go forth or away; to quit, leave, or separate, as from
      a place or a person; to withdraw; -- opposed to arrive; --
      often with from before the place, person, or thing left,
      and for or to before the destination.
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            I will depart to mine own land.       --Num. x. 30.
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            Ere thou from hence depart.           --Milton.
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            He which hath no stomach to this fight,
            Let him depart.                       --Shak.
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   3. To forsake; to abandon; to desist or deviate (from); not
      to adhere to; -- with from; as, we can not depart from our
      rules; to depart from a title or defense in legal
      pleading.
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            If the plan of the convention be found to depart
            from republican principles.           --Madison.
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   4. To pass away; to perish.
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            The glory is departed from Israel.    --1 Sam. iv.
                                                  21.
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   5. To quit this world; to die.
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            Lord, now lettest thou thy servant depart in peace.
                                                  --Luke ii. 29.
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   To depart with, to resign; to part with. [Obs.] --Shak.
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The Collaborative International Dictionary of English v.0.48:

Depart \De*part"\, v. t.
   1. To part thoroughly; to dispart; to divide; to separate.
      [Obs.]
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            Till death departed them, this life they lead.
                                                  --Chaucer.
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   2. To divide in order to share; to apportion. [Obs.]
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            And here is gold, and that full great plentee,
            That shall departed been among us three. --Chaucer.
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   3. To leave; to depart from. "He departed this life."
      --Addison. "Ere I depart his house." --Shak.
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The Collaborative International Dictionary of English v.0.48:

Depart \De*part"\, n. [Cf. F. d['e]part, fr. d['e]partir.]
   1. Division; separation, as of compound substances into their
      ingredients. [Obs.]
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            The chymists have a liquor called water of depart.
                                                  --Bacon.
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   2. A going away; departure; hence, death. [Obs.]
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            At my depart for France.              --Shak.
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            Your loss and his depart.             --Shak.
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WordNet (r) 3.0 (2006):

depart
    v 1: move away from a place into another direction; "Go away
         before I start to cry"; "The train departs at noon" [syn:
         go, go away, depart] [ant: come, come up]
    2: be at variance with; be out of line with [syn: deviate,
       vary, diverge, depart] [ant: conform]
    3: leave; "The family took off for Florida" [syn: depart,
       part, start, start out, set forth, set off, set
       out, take off]
    4: go away or leave [syn: depart, take leave, quit] [ant:
       stay]
    5: remove oneself from an association with or participation in;
       "She wants to leave"; "The teenager left home"; "She left her
       position with the Red Cross"; "He left the Senate after two
       terms"; "after 20 years with the same company, she pulled up
       stakes" [syn: leave, depart, pull up stakes]
    6: wander from a direct or straight course [syn: sidetrack,
       depart, digress, straggle]

Moby Thesaurus II by Grady Ward, 1.0:

219 Moby Thesaurus words for "depart":
   abandon, abrupt, abscond, absquatulate, alienate, be consumed,
   be getting along, be gone, be lost, beat a retreat, beat it, blow,
   bolt, bow out, buzz off, cast, cast off, cast out, cease,
   cease to be, cease to exist, cease to live, change, check out,
   clear out, come away, conk, croak, cut adrift, cut and run,
   cut off, cut out, decamp, decease, delete, dematerialize, demise,
   depart from, depart this life, desert, deviate, deviate from, die,
   die away, die out, differ, digress, disagree, disappear,
   disarticulate, discard, disconnect, disengage, disjoin, disjoint,
   dispel, disperse, dissent, dissipate, dissociate, dissolve,
   disunite, divagate, diverge, diverge from, divide, divorce,
   do a fade-out, duck out, dwindle, egress, eject, elope, erode,
   escape, estrange, evanesce, evaporate, excurse, exit, expel,
   expire, fade, fade away, fade out, fall, fall asleep, flee, fly,
   forsake, fugitate, gang along, get along, get away, get lost,
   get off, get on, get out, get sidetracked, get under way, go,
   go AWOL, go along, go astray, go away, go off, go on,
   go on furlough, go on leave, go out, hide, hit the road, isolate,
   jump, jump bail, leave, leave no trace, leave the scene, levant,
   make an exit, make off, march off, march out, maunder, melt,
   melt away, mosey, move away, move off, move out, part, pass,
   pass away, pass on, pass out, pass over, perish, pull away,
   pull back, pull out, put off mortality, quit, quit this world,
   ramble, reject, repudiate, retire, retire from sight,
   return to dust, run, run away, run away from, run away with,
   run for it, run off, run out, sashay, sashay off, scram, segregate,
   separate, sequester, set apart, set aside, set out, shove off,
   show the heels, shut off, sink, sink away, skedaddle, skip,
   skip out, slip away, slip off, slip out, slip the cable, sneak out,
   split, stagger along, stand aloof, stand apart, stand aside, start,
   step aside, stop breathing, stray, strike out, subtract, succumb,
   suffer an eclipse, take French leave, take flight, take leave,
   take to flight, take wing, throw off, throw out, toddle,
   toddle along, turn aside, turn tail, uncouple, unyoke, up and die,
   up and go, vamoose, vanish, vanish from sight, vary, walk out,
   wander, waste, waste away, wear away, wing it, withdraw,
   withdraw from, yield the ghost