The Collaborative International Dictionary of English v.0.48:

Botheration \Both`er*a"tion\, n.
   The act of bothering, or state of being bothered; cause of
   trouble; perplexity; annoyance; vexation. [Colloq.]
   [1913 Webster]

WordNet (r) 3.0 (2006):

botheration
    n 1: the psychological state of being irritated or annoyed [syn:
         irritation, annoyance, vexation, botheration]
    2: something or someone that causes trouble; a source of
       unhappiness; "washing dishes was a nuisance before we got a
       dish washer"; "a bit of a bother"; "he's not a friend, he's
       an infliction" [syn: annoyance, bother, botheration,
       pain, infliction, pain in the neck, pain in the ass]