The Collaborative International Dictionary of English v.0.48:

Befuddle \Be*fud"dle\, v. t. [imp. & p. p. Befuddled]
   To becloud and confuse, as with liquor.
   [1913 Webster]

WordNet (r) 3.0 (2006):

befuddle
    v 1: be confusing or perplexing to; cause to be unable to think
         clearly; "These questions confuse even the experts"; "This
         question completely threw me"; "This question befuddled
         even the teacher" [syn: confuse, throw, fox,
         befuddle, fuddle, bedevil, confound,
         discombobulate]
    2: make stupid with alcohol [syn: befuddle, fuddle]

Moby Thesaurus II by Grady Ward, 1.0:

49 Moby Thesaurus words for "befuddle":
   addle, addle the wits, ball up, becloud, bedazzle, bemuse, besot,
   bewilder, bother, bug, cloud, confuse, daze, dazzle,
   discombobulate, discomfit, discompose, disconcert, disorganize,
   disorient, distract, disturb, embarrass, entangle, flummox, flurry,
   fluster, flutter, fog, fuddle, fuss, inebriate, intoxicate, maze,
   mist, mix up, moider, muddle, perplex, perturb, pother, put out,
   raise hell, rattle, ruffle, throw into confusion, throw off,
   unsettle, upset