The Collaborative International Dictionary of English v.0.48:

Afflict \Af*flict"\, v. t. [imp. & p. p. Afflicted; p. pr. &
   vb. n. Afflicting.] [L. afflictus, p. p. of affigere to
   cast down, deject; ad + fligere to strike: cf. OF. aflit,
   afflict, p. p. Cf. Flagellate.]
   1. To strike or cast down; to overthrow. [Obs.] "Reassembling
      our afflicted powers." --Milton.
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   2. To inflict some great injury or hurt upon, causing
      continued pain or mental distress; to trouble grievously;
      to torment.
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            They did set over them taskmasters to afflict them
            with their burdens.                   --Exod. i. 11.
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            That which was the worst now least afflicts me.
                                                  --Milton.
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   3. To make low or humble. [Obs.] --Spenser.
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            Men are apt to prefer a prosperous error before an
            afflicted truth.                      --Jer. Taylor.
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   Syn: To trouble; grieve; pain; distress; harass; torment;
        wound; hurt.
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WordNet (r) 3.0 (2006):

afflicted
    adj 1: grievously affected especially by disease [syn:
           afflicted, stricken]
    2: mentally or physically unfit [syn: afflicted, impaired]

Moby Thesaurus II by Grady Ward, 1.0:

97 Moby Thesaurus words for "afflicted":
   abashed, agitated, agonized, bent, beset, boiled, bombed, boozy,
   bothered, canned, cast down, chagrined, chapfallen, cockeyed,
   cockeyed drunk, confused, convulsed, crocked, crocko, crucified,
   discomfited, discomforted, discomposed, disconcerted, disquieted,
   distressed, disturbed, doleful, dolorous, elevated, embarrassed,
   fried, fuddled, half-seas over, harrowed, high, hung up, hurt,
   hurting, ill at ease, illuminated, in distress, in pain, lacerated,
   lit, lit up, loaded, lubricated, lushy, martyred, martyrized,
   miserable, mortified, muzzy, oiled, on the rack, organized,
   out of countenance, pained, perturbed, pickled, pie-eyed, pissed,
   pissy-eyed, plastered, polluted, potted, put-out, put-upon, racked,
   raddled, rueful, ruthful, shellacked, skunk-drunk, smashed, soaked,
   sorrowful, soused, squiffy, stewed, stinko, suffering, swacked,
   tanked, tight, tormented, tortured, troubled, twisted,
   uncomfortable, under the harrow, uneasy, upset, wounded, wretched,
   wrung