The Collaborative International Dictionary of English v.0.48:

Scleroderma \Scler`o*der"ma\, n. [NL.] (Med.)
   A disease of adults, characterized by a diffuse rigidity and
   hardness of the skin.
   [1913 Webster]

WordNet (r) 3.0 (2006):

scleroderma
    n 1: an autoimmune disease that affects the blood vessels and
         connective tissue; fibrous connective tissue is deposited
         in the skin [syn: scleroderma, dermatosclerosis]
    2: genus of poisonous fungi having hard-skinned fruiting bodies:
       false truffles [syn: Scleroderma, genus Scleroderma]