The Collaborative International Dictionary of English v.0.48:

Ruin \Ru"in\, v. t. [imp. & p. p. Ruined;p. pr. & vb. n.
   Ruining.] [Cf. F. ruiner, LL. ruinare. See Ruin, n.]
   To bring to ruin; to cause to fall to pieces and decay; to
   make to perish; to bring to destruction; to bring to poverty
   or bankruptcy; to impair seriously; to damage essentially; to
   overthrow.
   [1913 Webster]

         this mortal house I'll ruin.             --Shak.
   [1913 Webster]

         By thee raised, I ruin all my foes.      --Milton.
   [1913 Webster]

         The eyes of other people are the eyes that ruin us.
                                                  --Franklin.
   [1913 Webster]

         By the fireside there are old men seated,
         Seeling ruined cities in the ashes.      --Longfellow.
   [1913 Webster]

WordNet (r) 3.0 (2006):

ruined
    adj 1: destroyed physically or morally [syn: destroyed,
           ruined]
    2: doomed to extinction [syn: done for(p), ruined, sunk,
       undone, washed-up]
    3: brought to ruin; "after the revolution the aristocracy was
       finished"; "the unsuccessful run for office left him ruined
       politically and economically" [syn: finished, ruined]

Moby Thesaurus II by Grady Ward, 1.0:

125 Moby Thesaurus words for "ruined":
   all up with, ausgespielt, bankrupt, battered, beat, beat-up,
   beaten, beaten up, bested, beyond recall, beyond remedy, blasted,
   blighted, botched, broke, broken, broken-down, busted, confounded,
   crumbling, cureless, decrepit, defeated, derelict, desolated,
   destitute, destroyed, devastated, dilapidated, discomfited,
   done for, done in, down, down-and-out, dusty, failed, fallen,
   finished, fixed, floored, fusty, gone, gone to pot, gone to seed,
   hors de combat, immedicable, in receivership, in ruins,
   incorrigible, incurable, inoperable, insolvent, irreclaimable,
   irrecoverable, irredeemable, irreformable, irremediable,
   irreparable, irretrievable, irreversible, irrevocable, kaput,
   lambasted, lathered, licked, lost, marred, mildewed, moldering,
   moldy, moss-grown, moth-eaten, musty, on the rocks, on the skids,
   outdone, overborne, overcome, overmastered, overmatched,
   overpowered, overridden, overthrown, overturned, overwhelmed,
   panicked, past hope, past praying for, put to rout, ramshackle,
   ravaged, remediless, routed, ruinous, run-down, rusty, scattered,
   settled, silenced, skinned, skinned alive, slummy, spoiled, spoilt,
   stale, stampeded, terminal, time-scarred, timeworn, tottery,
   trimmed, trounced, tumbledown, undone, unmitigable, unrelievable,
   unsalvable, unsalvageable, upset, wasted, whelmed, whipped, worn,
   worsted, wrecked