The Collaborative International Dictionary of English v.0.48:

Disinure \Dis`in*ure"\, v. t. [imp. & p. p. Disinured; p. pr.
   & vb. n. Disinuring.] [Pref. dis- + inure.]
   To render unaccustomed or unfamiliar.
   [1913 Webster]

         We are hindered and disinured . . . towards the true
         knowledge.                               --Milton.
   [1913 Webster]