The Collaborative International Dictionary of English v.0.48:

Wholesome \Whole"some\, a. [Compar. Wholesomer; superl.
   Wholesomest.] [Whole + some; cf. Icel. heilsamr, G.
   heilsam, D. heilzaam.]
   [1913 Webster]
   1. Tending to promote health; favoring health; salubrious;
      salutary.
      [1913 Webster]

            Wholesome thirst and appetite.        --Milton.
      [1913 Webster]

            From which the industrious poor derive an agreeable
            and wholesome variety of food.        --A Smith.
      [1913 Webster]

   2. Contributing to the health of the mind; favorable to
      morals, religion, or prosperity; conducive to good;
      salutary; sound; as, wholesome advice; wholesome
      doctrines; wholesome truths; wholesome laws.
      [1913 Webster]

            A wholesome tongue is a tree of life. --Prov. xv. 4.
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            I can not . . . make you a wholesome answer; my
            wit's diseased.                       --Shak.
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            A wholesome suspicion began to be entertained. --Sir
                                                  W. Scott.
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   3. Sound; healthy. [Obs.] --Shak.
      [1913 Webster] -- Whole"some*ly, adv. --
      Whole"some*ness, n.
      [1913 Webster]

WordNet (r) 3.0 (2006):

wholesome
    adj 1: conducive to or characteristic of physical or moral well-
           being; "wholesome attitude"; "wholesome appearance";
           "wholesome food" [ant: unwholesome]
    2: sound or exhibiting soundness in body or mind; "exercise
       develops wholesome appetites"; "a grin on his ugly wholesome
       face"

Moby Thesaurus II by Grady Ward, 1.0:

78 Moby Thesaurus words for "wholesome":
   admissible, all, all in all, all there, altogether, balanced,
   beneficial, benign, bracing, bunkum, clearheaded, clearminded,
   cogent, completely, compos mentis, constitutional, credible,
   curing, entirely, exactly, fit, fully, good, good for, hale,
   healing, health-enhancing, health-preserving, healthful, healthy,
   healthy-minded, hygeian, hygienic, in toto, invigorating, just,
   justifiable, legitimate, logical, lucid, mentally sound, normal,
   of sound mind, perfectly, plausible, purely, quite, rational,
   reasonable, refreshing, remedial, restorative, right, roundly,
   salubrious, salutary, sanative, sanatory, sane, sane-minded,
   sanitary, sensible, sound, sound-minded, thoroughly, together,
   tonic, totally, unimpaired, uninjurious, utterly, vulnerary, well,
   well-argued, well-founded, well-grounded, whole, wholly