The Collaborative International Dictionary of English v.0.48:

Spite \Spite\, n. [Abbreviated fr. despite.]
   1. Ill-will or hatred toward another, accompanied with the
      disposition to irritate, annoy, or thwart; petty malice;
      grudge; rancor; despite. --Pope.
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            This is the deadly spite that angers. --Shak.
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   2. Vexation; chargrin; mortification. [R.] --Shak.
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   In spite of, or Spite of, in opposition to all efforts
      of; in defiance or contempt of; notwithstanding.
      "Continuing, spite of pain, to use a knee after it had
      been slightly injured." --H. Spenser. "And saved me in
      spite of the world, the devil, and myself." --South. "In
      spite of all applications, the patient grew worse every
      day." --Arbuthnot. See Syn. under Notwithstanding.

   To owe one a spite, to entertain a mean hatred for him.
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   Syn: Pique, rancor; malevolence; grudge.

   Usage: Spite, Malice. Malice has more reference to the
          disposition, and spite to the manifestation of it in
          words and actions. It is, therefore, meaner than
          malice, thought not always more criminal. " Malice . .
          . is more frequently employed to express the
          dispositions of inferior minds to execute every
          purpose of mischief within the more limited circle of
          their abilities." --Cogan. "Consider eke, that spite
          availeth naught." --Wyatt. See Pique.
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The Collaborative International Dictionary of English v.0.48:

Spite \Spite\, v. t. [imp. & p. p. Spited; p. pr. & vb. n.
   Spiting.]
   1. To be angry at; to hate. [Obs.]
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            The Danes, then . . . pagans, spited places of
            religion.                             --Fuller.
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   2. To treat maliciously; to try to injure or thwart.
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   3. To fill with spite; to offend; to vex. [R.]
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            Darius, spited at the Magi, endeavored to abolish
            not only their learning, but their language. --Sir.
                                                  W. Temple.
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WordNet (r) 3.0 (2006):

spite
    n 1: feeling a need to see others suffer [syn: malice,
         maliciousness, spite, spitefulness, venom]
    2: malevolence by virtue of being malicious or spiteful or nasty
       [syn: cattiness, bitchiness, spite, spitefulness,
       nastiness]
    v 1: hurt the feelings of; "She hurt me when she did not include
         me among her guests"; "This remark really bruised my ego"
         [syn: hurt, wound, injure, bruise, offend,
         spite]