WordNet (r) 3.0 (2006):

DLE
    n 1: a chronic skin disease occurring primarily in women between
         the ages of 20 and 40; characterized by an eruption of red
         lesions over the cheeks and bridge of the nose [syn:
         discoid lupus erythematosus, DLE]

The Free On-line Dictionary of Computing (19 January 2023):

DLE

    Data Link Escape, the mnemonic for ASCII 16.

   (1996-06-24)