The Collaborative International Dictionary of English v.0.48:

Course \Course\ (k[=o]rs), n. [F. cours, course, L. cursus, fr.
   currere to run. See Current.]
   1. The act of moving from one point to another; progress;
      passage.
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            And when we had finished our course from Tyre, we
            came to Ptolemais.                    --Acts xxi. 7.
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   2. The ground or path traversed; track; way.
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            The same horse also run the round course at
            Newmarket.                            --Pennant.
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   3. Motion, considered as to its general or resultant
      direction or to its goal; line progress or advance.
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            A light by which the Argive squadron steers
            Their silent course to Ilium's well known shore.
                                                  --Dennham.
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            Westward the course of empire takes its way.
                                                  --Berkeley.
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   4. Progress from point to point without change of direction;
      any part of a progress from one place to another, which is
      in a straight line, or on one direction; as, a ship in a
      long voyage makes many courses; a course measured by a
      surveyor between two stations; also, a progress without
      interruption or rest; a heat; as, one course of a race.
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   5. Motion considered with reference to manner; or derly
      progress; procedure in a certain line of thought or
      action; as, the course of an argument.
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            The course of true love never did run smooth.
                                                  --Shak.
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   6. Customary or established sequence of events; recurrence of
      events according to natural laws.
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            By course of nature and of law.       --Davies.
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            Day and night,
            Seedtime and harvest, heat and hoary frost,
            Shall hold their course.              --Milton.
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   7. Method of procedure; manner or way of conducting; conduct;
      behavior.
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            My lord of York commends the plot and the general
            course of the action.                 --Shak.
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            By perseverance in the course prescribed.
                                                  --Wodsworth.
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            You hold your course without remorse. --Tennyson.
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   8. A series of motions or acts arranged in order; a
      succession of acts or practices connectedly followed; as,
      a course of medicine; a course of lectures on chemistry.
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   9. The succession of one to another in office or duty; order;
      turn.
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            He appointed . . . the courses of the priests --2
                                                  Chron. viii.
                                                  14.
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   10. That part of a meal served at one time, with its
       accompaniments.
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             He [Goldsmith] wore fine clothes, gave dinners of
             several courses, paid court to venal beauties.
                                                  --Macaulay.
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   11. (Arch.) A continuous level range of brick or stones of
       the same height throughout the face or faces of a
       building. --Gwilt.
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   12. (Naut.) The lowest sail on any mast of a square-rigged
       vessel; as, the fore course, main course, etc.
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   13. pl. (Physiol.) The menses.
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   In course, in regular succession.

   Of course, by consequence; as a matter of course; in
      regular or natural order.

   In the course of, at same time or times during. "In the
      course of human events." --T. Jefferson.

   Syn: Way; road; route; passage; race; series; succession;
        manner; method; mode; career; progress.
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WordNet (r) 3.0 (2006):

of course
    adv 1: as might be expected; "naturally, the lawyer sent us a
           huge bill" [syn: naturally, of course, course]
           [ant: unnaturally]

Moby Thesaurus II by Grady Ward, 1.0:

82 Moby Thesaurus words for "of course":
   OK, Roger, absolutely, accordingly, all right, alright, alrighty,
   amen, and no mistake, and so, as a consequence, as a result,
   as you say, assuredly, at all events, at any rate, aye,
   by all means, certainly, clearly, consequently, da, decidedly,
   decisively, definitely, distinctly, exactly, finally, fine,
   for a certainty, for a fact, for certain, for sure, forsooth, good,
   good enough, hear, in truth, inconsequence, indeed, indeedy,
   inevitably, it follows that, ja, just so, mais oui, most assuredly,
   most certainly, naturally, naturellement, necessarily,
   nothing else but, of necessity, okay, oui, positively, precisely,
   quite, rather, really, right, righto, sure, sure thing, surely,
   therefore, to a certainty, to be sure, truly, unequivocally,
   unmistakably, very well, well and good, why yes, yea, yeah, yep,
   yes, yes indeed, yes indeedy, yes sir, yes sirree



Bouvier's Law Dictionary, Revised 6th Ed (1856):

OF COURSE. That which may be done, in the course of legal proceedings,
without making any application to the court; that which is granted by the
court without further inquiry, upon its being asked; as, a rule to plead is
a matter of course.