WordNet (r) 3.0 (2006):

fly off the handle
    v 1: get very angry and fly into a rage; "The professor
         combusted when the student didn't know the answer to a very
         elementary question"; "Spam makes me go ballistic" [syn:
         flip one's lid, blow up, throw a fit, hit the roof,
         hit the ceiling, have kittens, have a fit, combust,
         blow one's stack, fly off the handle, flip one's wig,
         lose one's temper, blow a fuse, go ballistic]

Moby Thesaurus II by Grady Ward, 1.0:

32 Moby Thesaurus words for "fly off the handle":
   be angry, be excitable, bellow, blow a fuse, blow a gasket,
   blow up, catch fire, catch the infection, come apart,
   excite easily, explode, fire up, flame up, flare up, flash up,
   flip, fly out, get excited, go into hysterics, have a tantrum,
   hit the ceiling, rage, ramp, rant, rant and rave, rave,
   run a temperature, seethe, smolder, storm, take fire,
   turn a hair