The Collaborative International Dictionary of English v.0.48:

Alienate \Al"ien*ate\ ([=a]l"yen*[asl]t), a. [L. alienatus, p.
   p. of alienare, fr. alienus. See Alien, and cf. Aliene.]
   Estranged; withdrawn in affection; foreign; -- with from.
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         O alienate from God.                     --Milton.
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The Collaborative International Dictionary of English v.0.48:

Alienate \Al"ien*ate\ (-[=a]t), v. t. [imp. & p. p. Alienated;
   p. pr. & vb. n. Alienating.]
   1. To convey or transfer to another, as title, property, or
      right; to part voluntarily with ownership of.
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   2. To withdraw, as the affections; to make indifferent of
      averse, where love or friendship before subsisted; to
      estrange; to wean; -- with from.
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            The errors which . . . alienated a loyal gentry and
            priesthood from the House of Stuart.  --Macaulay.
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            The recollection of his former life is a dream that
            only the more alienates him from the realities of
            the present.                          --I. Taylor.
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The Collaborative International Dictionary of English v.0.48:

Alienate \Al"ien*ate\, n.
   A stranger; an alien. [Obs.]
   [1913 Webster]

WordNet (r) 3.0 (2006):

alienate
    v 1: arouse hostility or indifference in where there had
         formerly been love, affection, or friendliness; "She
         alienated her friends when she became fanatically
         religious" [syn: estrange, alienate, alien,
         disaffect]
    2: transfer property or ownership; "The will aliened the
       property to the heirs" [syn: alien, alienate]
    3: make withdrawn or isolated or emotionally dissociated; "the
       boring work alienated his employees"