The Collaborative International Dictionary of English v.0.48:

Handcuff \Hand"cuff`\ (-k[u^]f`), n. [AS. handcops; hand hand +
   cosp, cops, fetter. The second part was confused with E.
   cuffs,]
   A fastening, consisting of an iron ring around the wrist,
   usually connected by a chain with one on the other wrist; a
   manacle; -- usually in the plural.
   [1913 Webster]

The Collaborative International Dictionary of English v.0.48:

Handcuff \Hand"cuff`\ (h[a^]nd"k[u^]f`), v. t. [imp. & p. p.
   Handcuffed (-k[u^]ft`); p. pr. & vb. n. Handcuffing.]
   To apply handcuffs to; to manacle. --Hay (1754).
   [1913 Webster]

WordNet (r) 3.0 (2006):

handcuff
    n 1: shackle that consists of a metal loop that can be locked
         around the wrist; usually used in pairs [syn: handcuff,
         cuff, handlock, manacle]
    v 1: confine or restrain with or as if with manacles or
         handcuffs; "The police handcuffed the suspect at the scene
         of the crime" [syn: manacle, cuff, handcuff]