The Collaborative International Dictionary of English v.0.48:

Spotted \Spot"ted\, a.
   Marked with spots; as, a spotted garment or character. "The
   spotted panther." --Spenser.
   [1913 Webster]

   Spotted fever (Med.), a name applied to various eruptive
      fevers, esp. to typhus fever and cerebro-spinal
      meningitis.

   Spotted tree (Bot.), an Australian tree (Flindersia
      maculosa); -- so called because its bark falls off in
      spots.
      [1913 Webster]

WordNet (r) 3.0 (2006):

spotted fever
    n 1: any of several severe febrile diseases characterized by
         skin rashes or spots on the skin