The Collaborative International Dictionary of English v.0.48:

Manuscript \Man"u*script\, a. [L. manu scriptus. See Manual,
   and Scribe.]
   Written with or by the hand; not printed; as, a manuscript
   volume.
   [1913 Webster]

The Collaborative International Dictionary of English v.0.48:

Manuscript \Man"u*script\, n. [LL. manuscriptum, lit., something
   written with the hand. See Manuscript, a.]
   1. An original literary or musical composition written by the
      author, formerly with the hand, now usually by typewriter
      or word processor. It is contrasted with a printed copy.
      [1913 Webster +PJC]

   2. Writing, as opposed to print; as, the book exists only in
      manuscript. --Craik.
      [1913 Webster]

   Note: The word is often abbreviated to MS., plural MSS.
         [1913 Webster]

WordNet (r) 3.0 (2006):

manuscript
    n 1: the form of a literary work submitted for publication [syn:
         manuscript, ms]
    2: handwritten book or document [syn: manuscript, holograph]