The Collaborative International Dictionary of English v.0.48:

Depart \De*part"\, v. i. [imp. & p. p. Departed; p. pr. & vb.
   n. Departing.] [OE. departen to divide, part, depart, F.
   d['e]partir to divide, distribute, se d['e]partir to separate
   one's self, depart; pref. d['e]- (L. de) + partir to part,
   depart, fr. L. partire, partiri, to divide, fr. pars part.
   See Part.]
   1. To part; to divide; to separate. [Obs.] --Shak.
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   2. To go forth or away; to quit, leave, or separate, as from
      a place or a person; to withdraw; -- opposed to arrive; --
      often with from before the place, person, or thing left,
      and for or to before the destination.
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            I will depart to mine own land.       --Num. x. 30.
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            Ere thou from hence depart.           --Milton.
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            He which hath no stomach to this fight,
            Let him depart.                       --Shak.
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   3. To forsake; to abandon; to desist or deviate (from); not
      to adhere to; -- with from; as, we can not depart from our
      rules; to depart from a title or defense in legal
      pleading.
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            If the plan of the convention be found to depart
            from republican principles.           --Madison.
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   4. To pass away; to perish.
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            The glory is departed from Israel.    --1 Sam. iv.
                                                  21.
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   5. To quit this world; to die.
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            Lord, now lettest thou thy servant depart in peace.
                                                  --Luke ii. 29.
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   To depart with, to resign; to part with. [Obs.] --Shak.
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The Collaborative International Dictionary of English v.0.48:

Depart \De*part"\, v. t.
   1. To part thoroughly; to dispart; to divide; to separate.
      [Obs.]
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            Till death departed them, this life they lead.
                                                  --Chaucer.
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   2. To divide in order to share; to apportion. [Obs.]
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            And here is gold, and that full great plentee,
            That shall departed been among us three. --Chaucer.
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   3. To leave; to depart from. "He departed this life."
      --Addison. "Ere I depart his house." --Shak.
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The Collaborative International Dictionary of English v.0.48:

Depart \De*part"\, n. [Cf. F. d['e]part, fr. d['e]partir.]
   1. Division; separation, as of compound substances into their
      ingredients. [Obs.]
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            The chymists have a liquor called water of depart.
                                                  --Bacon.
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   2. A going away; departure; hence, death. [Obs.]
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            At my depart for France.              --Shak.
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            Your loss and his depart.             --Shak.
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WordNet (r) 3.0 (2006):

depart
    v 1: move away from a place into another direction; "Go away
         before I start to cry"; "The train departs at noon" [syn:
         go, go away, depart] [ant: come, come up]
    2: be at variance with; be out of line with [syn: deviate,
       vary, diverge, depart] [ant: conform]
    3: leave; "The family took off for Florida" [syn: depart,
       part, start, start out, set forth, set off, set
       out, take off]
    4: go away or leave [syn: depart, take leave, quit] [ant:
       stay]
    5: remove oneself from an association with or participation in;
       "She wants to leave"; "The teenager left home"; "She left her
       position with the Red Cross"; "He left the Senate after two
       terms"; "after 20 years with the same company, she pulled up
       stakes" [syn: leave, depart, pull up stakes]
    6: wander from a direct or straight course [syn: sidetrack,
       depart, digress, straggle]