The Collaborative International Dictionary of English v.0.48:

Offend \Of*fend\, v. t. [imp. & p. p. Offended; p. pr. & vb.
   n. Offending.] [OF. offendre, L. offendere, offensum; ob
   (see Ob-) + fendere (in comp.) to thrust, dash. See
   Defend.]
   1. To strike against; to attack; to assail. [Obs.] --Sir P.
      Sidney.
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   2. To displease; to make angry; to affront.
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            A brother offended is harder to be won than a strong
            city.                                 --Prov. xviii.
                                                  19.
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   3. To be offensive to; to harm; to pain; to annoy; as, strong
      light offends the eye; to offend the conscience.
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   4. To transgress; to violate; to sin against. [Obs.]
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            Marry, sir, he hath offended the law. --Shak.
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   5. (Script.) To oppose or obstruct in duty; to cause to
      stumble; to cause to sin or to fall. [Obs.]
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            Who hath you misboden or offended.    --Chaucer.
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            If thy right eye offend thee, pluck it out . . . And
            if thy right hand offend thee, cut it off. --Matt.
                                                  v. 29, 3O.
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            Great peace have they which love thy law, and
            nothing shall offend them.            --Ps. cxix.
                                                  165.
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The Collaborative International Dictionary of English v.0.48:

Offend \Of*fend"\, v. i.
   1. To transgress the moral or divine law; to commit a crime;
      to stumble; to sin.
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            Whosoever shall keep the whole law, and yet offend
            in one point, he is guilty of all.    --James ii.
                                                  10.
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            If it be a sin to covet honor,
            I am the most offending soul alive.   --Shak.
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   2. To cause dislike, anger, or vexation; to displease.
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            I shall offend, either to detain or give it. --Shak.
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   To offend against, to do an injury or wrong to; to commit
      an offense against. "We have offended against the Lord
      already." --2 Chron. xxviii. 13.
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WordNet (r) 3.0 (2006):

offend
    v 1: cause to feel resentment or indignation; "Her tactless
         remark offended me" [syn: pique, offend]
    2: act in disregard of laws, rules, contracts, or promises;
       "offend all laws of humanity"; "violate the basic laws or
       human civilization"; "break a law"; "break a promise" [syn:
       transgress, offend, infract, violate, go against,
       breach, break] [ant: keep, observe]
    3: strike with disgust or revulsion; "The scandalous behavior of
       this married woman shocked her friends" [syn: shock,
       offend, scandalize, scandalise, appal, appall,
       outrage]
    4: hurt the feelings of; "She hurt me when she did not include
       me among her guests"; "This remark really bruised my ego"
       [syn: hurt, wound, injure, bruise, offend, spite]