The Collaborative International Dictionary of English v.0.48:HS1 \HS1\, HSV-1 \HSV-1\, HSV-I \HSV-I\n. 1. Herpes simplex 1, a herpes virus that causes oral herpes; also called type I Herpes. Syn: herpes simplex 1. [WordNet 1.5] HSV-2 HS2