The Collaborative International Dictionary of English v.0.48:
Melpomene \Mel*pom"e*ne\, n. [L., fr. Gr. ?, lit., the songstress, fr. ?, ?, to sing.] 1. (Class. Myth.) The Muse of tragedy. [1913 Webster] 2. (Astron.) The eighteenth asteroid. [1913 Webster]WordNet (r) 3.0 (2006):
Melpomene n 1: (Greek mythology) the Muse of tragedy