The Collaborative International Dictionary of English v.0.48:

Holmes \Holmes\ n.
   Sherlock Holmes, a fictitious detective in novels by A. Conan
   Doyle.

   Syn: Sherlock Holmes.
        [WordNet 1.5]

WordNet (r) 3.0 (2006):

Holmes
    n 1: a fictitious detective in stories by A. Conan Doyle [syn:
         Sherlock Holmes, Holmes]
    2: United States jurist noted for his liberal opinions
       (1841-1935) [syn: Holmes, Oliver Wendell Holmes Jr.]
    3: United States writer of humorous essays (1809-1894) [syn:
       Holmes, Oliver Wendell Holmes]
    4: English geologist and supporter of the theory of continental
       drift (1890-1965) [syn: Holmes, Arthur Holmes]

U.S. Gazetteer Counties (2000):

Holmes -- U.S. County in Mississippi
   Population (2000):    21609
   Housing Units (2000): 8439
   Land area (2000):     755.999831 sq. miles (1958.030490 sq. km)
   Water area (2000):    8.180655 sq. miles (21.187799 sq. km)
   Total area (2000):    764.180486 sq. miles (1979.218289 sq. km)
   Located within:       Mississippi (MS), FIPS 28
   Location:             33.108092 N, 90.054764 W
   Headwords:
    Holmes
    Holmes, MS
    Holmes County
    Holmes County, MS


U.S. Gazetteer Counties (2000):

Holmes -- U.S. County in Ohio
   Population (2000):    38943
   Housing Units (2000): 12280
   Land area (2000):     422.991850 sq. miles (1095.543815 sq. km)
   Water area (2000):    1.027895 sq. miles (2.662237 sq. km)
   Total area (2000):    424.019745 sq. miles (1098.206052 sq. km)
   Located within:       Ohio (OH), FIPS 39
   Location:             40.561178 N, 81.928992 W
   Headwords:
    Holmes
    Holmes, OH
    Holmes County
    Holmes County, OH


U.S. Gazetteer Counties (2000):

Holmes -- U.S. County in Florida
   Population (2000):    18564
   Housing Units (2000): 7998
   Land area (2000):     482.448855 sq. miles (1249.536744 sq. km)
   Water area (2000):    6.258624 sq. miles (16.209761 sq. km)
   Total area (2000):    488.707479 sq. miles (1265.746505 sq. km)
   Located within:       Florida (FL), FIPS 12
   Location:             30.853637 N, 85.785748 W
   Headwords:
    Holmes
    Holmes, FL
    Holmes County
    Holmes County, FL