The Collaborative International Dictionary of English v.0.48:

Ail \Ail\ ([=a]l), v. t. [imp. & p. p. Ailed ([=a]ld); p. pr.
   & vb. n. Ailing.] [OE. eilen, ailen, AS. eglan to trouble,
   pain; akin to Goth. us-agljan to distress, agls troublesome,
   irksome, aglo, aglitha, pain, and prob. to E. awe. [root]3.]
   To affect with pain or uneasiness, either physical or mental;
   to trouble; to be the matter with; -- used to express some
   uneasiness or affection, whose cause is unknown; as, what
   ails the man? I know not what ails him.
   [1913 Webster]

         What aileth thee, Hagar?                 --Gen. xxi.
                                                  17.
   [1913 Webster]

   Note: It is never used to express a specific disease. We do
         not say, a fever ails him; but, something ails him.
         [1913 Webster]