The Collaborative International Dictionary of English v.0.48:

Profligate \Prof"li*gate\, a. [L. profligatus, p. p. of
   profligare to strike or dash to the ground, to destroy; pro
   before + a word akin to fligere to strike. See Afflict.]
   [1913 Webster]
   1. Overthrown; beaten; conquered. [Obs.]
      [1913 Webster]

            The foe is profligate, and run.       --Hudibras.
      [1913 Webster]

   2. Broken down in respect of rectitude, principle, virtue, or
      decency; openly and shamelessly immoral or vicious;
      dissolute; as, profligate man or wretch.
      [1913 Webster]

            A race more profligate than we.       --Roscommon.
      [1913 Webster]

            Made prostitute and profligate muse.  --Dryden.
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   Syn: Abandoned; corrupt; dissolute; vitiated; depraved;
        vicious; wicked. See Abandoned.
        [1913 Webster]

The Collaborative International Dictionary of English v.0.48:

Profligate \Prof"li*gate\, n.
   An abandoned person; one openly and shamelessly vicious; a
   dissolute person. "Such a profligate as Antony." --Swift.
   [1913 Webster]

The Collaborative International Dictionary of English v.0.48:

Profligate \Prof"li*gate\, v. t.
   To drive away; to overcome.

   Note: [A Latinism] [Obs.] --Harvey.
         [1913 Webster]

WordNet (r) 3.0 (2006):

profligate
    adj 1: recklessly wasteful; "prodigal in their expenditures"
           [syn: extravagant, prodigal, profligate,
           spendthrift]
    2: unrestrained by convention or morality; "Congreve draws a
       debauched aristocratic society"; "deplorably dissipated and
       degraded"; "riotous living"; "fast women" [syn: debauched,
       degenerate, degraded, dissipated, dissolute,
       libertine, profligate, riotous, fast]
    n 1: a dissolute man in fashionable society [syn: rake,
         rakehell, profligate, rip, blood, roue]
    2: a recklessly extravagant consumer [syn: prodigal,
       profligate, squanderer]

Moby Thesaurus II by Grady Ward, 1.0:

124 Moby Thesaurus words for "profligate":
   Casanova, Don Juan, Lothario, abandoned, backslider, bad egg,
   bad lot, black sheep, carnal, contaminated, corrupt, corrupted,
   debased, debauched, debauchee, decadent, degenerate, degraded,
   depraved, dissipated, dissipative, dissolute, easy come, easy go,
   erotic, evil, excessive, extravagant, fallen angel, fast, free,
   gallant, gay, gay deceiver, gay dog, good-for-nothing, immoderate,
   immoral, improvident, incontinent, indecent, iniquitous,
   intemperate, lady-killer, lascivious, lavish, lecher, lecherous,
   lewd, libertine, licentious, loose, lost sheep, lost soul,
   lover-boy, miscreant, morally polluted, no-good, overgenerous,
   overlavish, overliberal, penny-wise and pound-foolish, pervert,
   perverted, philanderer, pimp, polluted, pound-foolish, prodigal,
   profuse, promiscuous, rake, rakehell, rakehellish, rakehelly,
   rakish, recidivist, reckless, recreant, reprobate, rip, rotten,
   roue, rounder, scapegrace, sensual, sensualist, shameless, sinful,
   sinner, skirt chaser, sodomite, sorry lot, spender, spendthrift,
   squanderer, squandering, steeped in iniquity, swinger, sybarite,
   sybaritic, tainted, trollop, unbridled, unprincipled, unrestrained,
   vice-corrupted, vitiated, voluptuary, voluptuous, walking phallus,
   wanton, warped, wasteful, waster, wastethrift, wastrel, whore,
   whoremonger, wicked, wild, wolf, woman chaser, womanizer