The Collaborative International Dictionary of English v.0.48:

Misfortune \Mis*for"tune\, n.
   Bad fortune or luck; calamity; an evil accident; disaster;
   mishap; mischance.
   [1913 Webster]

         Consider why the change was wrought,
         You 'll find his misfortune, not his fault. --Addison.
   [1913 Webster]

   Syn: Calamity; mishap; mischance; misadventure; ill; harm;
        disaster. See Calamity.
        [1913 Webster]

The Collaborative International Dictionary of English v.0.48:

Misfortune \Mis*for"tune\, v. i.
   To happen unluckily or unfortunately; to miscarry; to fail.
   [Obs.] --Stow.
   [1913 Webster]

WordNet (r) 3.0 (2006):

misfortune
    n 1: unnecessary and unforeseen trouble resulting from an
         unfortunate event [syn: misfortune, bad luck]
    2: an unfortunate state resulting from unfavorable outcomes
       [syn: misfortune, bad luck, tough luck, ill luck]
       [ant: good fortune, good luck, luckiness]

Moby Thesaurus II by Grady Ward, 1.0:

39 Moby Thesaurus words for "misfortune":
   accident, adversity, bad luck, bad news, blow, calamity, casualty,
   cataclysm, catastrophe, collision, contretemps, crack-up, crash,
   cross, disaster, dole, grief, hard luck, ill fortune, ill hap,
   ill luck, infelicity, loss, misadventure, mischance, mishap,
   nasty blow, pileup, reverse, shipwreck, shock, smash, smashup,
   staggering blow, tragedy, trial, tribulation, visitation, wreck



The Devil's Dictionary (1881-1906):

MISFORTUNE, n.  The kind of fortune that never misses.