The Collaborative International Dictionary of English v.0.48:

Meddle \Med"dle\, v. t.
   To mix; to mingle. [Obs.] --Chaucer.
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         "Wine meddled with gall."                --Wyclif
                                                  (Matt. xxvii.
                                                  34).
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The Collaborative International Dictionary of English v.0.48:

Meddle \Med"dle`\, v. i. [imp. & p. p. Meddled; p. pr. & vb.
   n. Meddling.] [OE. medlen to mix, OF. medler, mesler, F.
   m[^e]ler, LL. misculare, a dim. fr. L. miscere to mix.
   [root]271. See Mix, and cf. Medley, Mellay.]
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   1. To mix; to mingle. [Obs.]
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            More to know
            Did never meddle with my thoughts.    --Shak.
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   2. To interest or engage one's self; to have to do; -- in a
      good sense. [Obs.] --Barrow.
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            Study to be quiet, and to meddle with your own
            business.                             --Tyndale.
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   3. To interest or engage one's self unnecessarily or
      impertinently, to interfere or busy one's self improperly
      with another's affairs; specifically, to handle or distrub
      another's property without permission; -- often followed
      by with or in.
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            Why shouldst thou meddle to thy hurt? --2 Kings xiv.
                                                  10.
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            The civil lawyers . . . have meddled in a matter
            that belongs not to them.             --Locke.
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   To meddle and make, to intrude one's self into another
      person's concerns. [Archaic] --Shak.
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   Syn: To interpose; interfere; intermeddle.
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WordNet (r) 3.0 (2006):

meddle
    v 1: intrude in other people's affairs or business; interfere
         unwantedly; "Don't meddle in my affairs!" [syn: meddle,
         tamper]

Moby Thesaurus II by Grady Ward, 1.0:

73 Moby Thesaurus words for "meddle":
   Paul-Pry, advise, advocate, arrest, bottle up, brief, busybody,
   butt in, check, coach, confer, consult with, counsel, countercheck,
   curb, dam up, damp, dampen, delay, detain, direct, fool, fool with,
   guide, hinder, hold back, hold in check, hold up, horn in, impede,
   inhibit, instruct, intercept, interfere, interlope, intermeddle,
   interrupt, intervene, intrude, invade, keep back, keep in check,
   kibitz, make, meddle with, mess around, mess with, monkey with,
   nose, obtrude, oppose, peek, peep, prescribe, propose, pry,
   recommend, repress, resist, restrain, retard, scotch, set back,
   slacken, snoop, snub, spy, submit, suggest, suppress, tamper,
   tamper with, trespass