The Collaborative International Dictionary of English v.0.48:

Estrange \Es*trange"\, v. t. [imp. & p. p. Estranged; p. pr. &
   vb. n. Estranging.] [OF. estrangier to remove, F.
   ['e]tranger, L. extraneare to treat as a stranger, from
   extraneus strange. See Strange.]
   1. To withdraw; to withhold; hence, reflexively, to keep at a
      distance; to cease to be familiar and friendly with.
      [1913 Webster]

            We must estrange our belief from everything which is
            not clearly and distinctly evidenced. --Glanvill.
      [1913 Webster]

            Had we . . . estranged ourselves from them in things
            indifferent.                          --Hooker.
      [1913 Webster]

   2. To divert from its original use or purpose, or from its
      former possessor; to alienate.
      [1913 Webster]

            They . . . have estranged this place, and have
            burned incense in it unto other gods. --Jer. xix. 4.
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   3. To alienate the affections or confidence of; to turn from
      attachment to enmity or indifference.
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            I do not know, to this hour, what it is that has
            estranged him from me.                --Pope.
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            He . . . had pretended to be estranged from the
            Whigs, and had promised to act as a spy upon them.
                                                  --Macaulay.
      [1913 Webster]

WordNet (r) 3.0 (2006):

estrange
    v 1: remove from customary environment or associations; "years
         of boarding school estranged the child from her home"
    2: arouse hostility or indifference in where there had formerly
       been love, affection, or friendliness; "She alienated her
       friends when she became fanatically religious" [syn:
       estrange, alienate, alien, disaffect]

Moby Thesaurus II by Grady Ward, 1.0:

72 Moby Thesaurus words for "estrange":
   abrupt, aggravate, alien, alienate, antagonize, break up, cast off,
   cast out, come between, cut adrift, cut off, cut out, delete,
   depart, disaffect, disarticulate, disconnect, disengage, disjoin,
   disjoint, dissociate, disunify, disunite, divide, divorce, eject,
   embitter, envenom, exacerbate, expel, fan the flame, heat up,
   infuriate, irritate, isolate, leave, light the fuse, madden,
   make trouble, part, pit against, provoke, pull away, pull back,
   pull out, segregate, separate, sequester, set against, set apart,
   set aside, set at odds, set at variance, set on, sever, shut off,
   sic on, sow dissension, split, stand aloof, stand apart,
   stand aside, step aside, stir up trouble, subtract, sunder,
   throw off, throw out, uncouple, unyoke, wean, withdraw